DNA Damage Recognition & Tolerance Laboratory
Department of Chemistry and Chemical Biology at Northeastern University
The interests of Professor Beuning’s lab are to understand cellular responses to genotoxic stress. All organisms experience damage to their genetic material from environmental and endogenous sources. Multiple redundant systems exist to identify and remove damaged bases from DNA in organisms from bacteria to humans. For example, the bacterial SOS response, involving the upregulation of at least 40 genes in E. coli, is induced when cells experience damage to their DNA and other stresses. Many of the genes induced as part of the SOS response are responsible for DNA repair and cell cycle regulation. Another group of genes induced as part of the SOS response play a role in tolerance to DNA damaging agents at a potentially mutagenic cost.
Beuning Lab receives two new grants>>
Prof. Beuning receives NSF CAREER award >>
Prof. Beuning named 2009 Cottrell Scholar >>
Ali Wallace Receives Merck Scholarship for summer research.
NU Researchers Discover new DNA Binding Activity of E. coli DNA Polymerase >>
Michelle Silva Receives Outstanding TA Award
Michelle Silva, graduate student in the laboratory, received a Dept of Chemistry and Chemical Biology Outstanding TA Award.
Prof. Beuning Receives Dreyfus New Faculty Award
Prof. Beuning was awarded a New Faculty Award from the Camille and Henry Dreyfus Foundation. Learn More
Department of Chemistry and Chemical Biology